Bioprocess Container Systems
Charter Medical, Ltd. is a leader in the design and manufacture of highly specialized flexible containers for the pharmaceutical and biotechnology industries. Charter Medical offers a family of biopharmaceutical containers and sampling technology that helps you speed your product to market. All products are manufactured in the USA.
We supply the Biotech and BioPharm industries with:
Bio-Pak® XL Bioprocess Container
The Charter Bio-Pak® XL series containers are an efficient and cost-effective alternative to large tanks and carboys for sterile fluid containment and processing. The single use Bio-Pak® XL bags eliminate the issues surrounding cleaning validation, storage and sterilizing of traditional containers. In addition, they are lightweight, easy to fill, and easier to handle than large glass or steel tanks. The Bio-Pak® XL Plus containers include built-in 0.22um hydrophilic filters. Bio-Pak® XL containers can be custom-configured with the right combination of inlets, tubing, filters and sampling outlets to suit a specific process. Compared to steel tanks, which require custom assembly and sterilization before each use, these pre-assembled bags present tremendous time savings.
BP Small Volume Containers
The Charter Medical BP containers range in size from 30mL to 25L, and are a cost-effective alternative to rigid glass and plastic bottles. The single use BP-Minis eliminate the issues surrounding cleaning validation, storage and sterilizing of traditional containers. They are lightweight, easy to fill, and more convenient to handle than conventional rigid bottles.
Bio-Fill Disposable Bioprocess Containers
For the Sterile Filtration of: Tissue Culture Media, Buffers, and other Aqueous Solutions
Bio-Fill containers were designed specifically for bioprocess areas such as process
development, where the sterile filtration of aqueous solutions, specifically cell culture media is critical. The Bio-Fill combines the easy-use funnel style sterile filtration with the convenience of a single-use bioprocess bag for the collection and transport of the sterilized product. Each system is sterilized by gamma-irradiation.
2 units are available to work with volumes between 1L and 2L, and between 3L and –
- Product Bag – Ethylene Vinyl Acetate (EVA) with 3 ports with quick disconnects
- Hanging bag for easy draining
- Millipore Express Plus® (PES) Steritop® filter unit featuring
- Low Protein Binding
- High Flow and Throughput
- Vacuum driven or peristaltic pump
Product Catalog
| Catalog No. |
Description |
Case Qty |
| BFO2000MPB |
1000mL Funnel System with 2000mL Bag System for 200 - 2000mL samles |
6 |
| BFO5000MPB |
1000mL Funnel System with 5000mL Bag System for 2L - 5L samples |
6 |
Cell Culture Bags for Rocking Platform -
Bioreactors
Main applications include insect/baculovirus culture, monoclonal antibody production, recombinant protein manufacturing, cell line expansion, virus manufacturing in gene therapy applications, culture of anchorage dependant cells, GMP production, recombinant vaccine manufacturing.
Charter Medical disposable cell culture bags can be used on existing rocking platform bioreactor systems without any modification and without purchasing any additional equipment.
Charter cell culture bags can be supplied in a range of film types depending on usage, protein adsorption and extractable requirements. The most common types are:
Charter cell culture bags are pre-assembled, sterile and ready to use.
Charter cell culture bags can be custom designed to exactly match your requirements and are available with a wide range of configurations of:
-
Ports
- Tubing
- Filters
-
 |
| Above are photographs of both a 20L and a 200L cell culture bag |
Connectors
Cell culture bags are manufactured:
- under cGMP conditions
- in ISO Class 7 clean suites
- in an FDA registered medical device manufacturing facility
|
Cell culture bags:
- are non-hemolytic (direct contact method)
- non cytotoxic (USP<87>)
- pass USP purified water test for oxidizable substances
- contain<0.05EU/mL by the LAL test
- meet or exceed Physicochemical Tests for Plastic Containers (USP<661>)
|
- Most films are filed with the FDA under individual Drug Master File numbers.
- All bags have full CAD-CAM drawing and bill of materials support documentation.
- Full extractable data is available for all films used.
- Bags are available in sizes between 2 and 200L, see ordering information below.
Product Catalog
| Catalog No. |
Description |
Case Qty |
| CML-2L-CELL38 |
2 Liter Cell Culture Bag |
10 |
| CML-20L-CELL |
20 Liter Cell Culture Bag |
6 |
| CML-20L-CELL38 |
20 Liter Cell Culture Bag w 1/2" ID Tubing |
6 |
Contour Tank Liners
Charter Medical's single use, Contour Tank Liners are a cost-effective alternative to dedicated tanks & carboys. Contour liners eliminate the issues surrounding cleaning validation and sterilizing of traditional containers. Most importantly, because they are single use, the problem of cross-contamination between different products is virtually eliminated. One rigid plastic container equipped with a fresh liner can be used to process and mix a variety of different products.
Bio-Trans(Stainless Steel)
Charter offers application-designed, mobile container handling units mounted on durable, non-marking wheels. These tough stainless steel totes hold the flexible bags plus outlet tubing in a self-contained, wheeled unit that can even be transported by forklift. A uniquely designed bottom outlet system allows fast flow rates and minimal container holdup volume. |
